Get Bremelanotide or PT 141 Research Peptide Online – Features & Effects
Bremelanotide or pt 141 is a commercially-produced version of alpha-MSH (melanocyte-stimulating hormone). The peptide is synthesized endogenously. Alpha-MSH has numerous effects in a biological system, most of which include enhancing libido, lipid metabolism and appetite. According to pt 141 reviews, the peptide is seen to act on specific receptors such as the MC4R and MC3R. The peptide is under research investigations to determine its function as a remedy for sexual dysfunctions, hemorrhagic shock and reperfusion injuries.
Melanotan 2 predecessor, bremelanotide or Melanotan 1, has undergone numerous testings to determine its effectiveness in inducing sunless tanning. Moreover, the peptide has been known to cause sexual arousal and spontaneous erections on test mice subjects. Research done on mice indicated that the pt 141 peptide has positive feedback on sexual dysfunctions such as erectile dysfunction in male rats and arousal disorders in female rats. The application of the peptide can vary from subject to subject. It can be applied intravenously, through the nasal cavity and orally. There are some side effects expected from the administration of the peptide and one of them is an increase in blood pressure. According to different reviews on pt 141, it is touted as the most effective aphrodisiac. However, all these information is still under scrutiny. PT 141 is essential in increasing libido and acts on the central nervous system and not in the vascular system as other common peptides do. The target of the peptide is the brain arousal center and it affects an increase in libido through the activation and stimulation of the melanocortin receptors. According to research, test mice showed an increase in blood flow to the reproductive organs. In female rats, they became active and looked for their male counterparts.
The pt 141 peptide has shown activity from 6-72 hours. It is supplied in vials of 10 mg which is the industry standard. However, for research purposes, the peptide can be supplied in 2 mg vials which are convenient for transit. The pt 141 peptide is supplied in powder or freeze-dried and should be kept in 2-8 degree Celsius to preserve its integrity. Most peptides are sensitive to changes in temperature and pressure. A 10 mg vial can supply up to 20 doses on the research subject which is enough for making some conclusions. A high quality peptide should be reconstituted using bacteriostatic water or saline water and should be stored in a freezer when not in use. The test dosage is usually 0.25 mg to 0.5 mg. However, the dosage can be increased up to 2 mg to elicit the required reaction.
The pt 141 peptide is currently under investigation for managing different problems such as reperfusion injury, hemorrhagic shock and sexual dysfunctions. The main objective of the study is to identify the effects of the peptide in the stimulation of sexual arousal in women and erectile dysfunction in men. According to the study done on mice, hops and darts, heart racing and soliciting sexual behaviors were seen and brain assessment confirmed the postulate. Using special molecular markers of heightened activation in the mice sexual activity, the results showed that the hypothalamic and limbic regions in the mice were activated and the mPOA terminals were activated. This led to an increase in the levels of dopamine in the brain.
Mechanism of Action
The pt 141 review indicated that the peptide has seven amino acids in its sequence and it is a cyclic molecule, therefore, a lactam derivative. The peptide acts through the stimulation of melanocortin receptors situated in the central nervous system. The peptide has the potential of growing to be one of the most sought since it has numerous beneficial features that are still under investigation. There is a high possibility that after approval, the peptide could be used to treat arousal disorders and erectile dysfunctions.
The pt 141 peptide has a molecular weight of 1.025-kilo Daltons. In addition, it is not a vasoactive compound – it acts directly on the central nervous system to elicit the desired reaction. In the past, there have been many studies that tried to identify the possibility of using the pt 141 peptide to treat numerous conditions. The peptide works as an agonist to the melanocortin peptide hormone and is known to activate MC4R and MC3R receptors. The hormone is important in stimulating the conversion of eumelanin to melanin on epidermal cells of the skin in a process referred to as melanogenesis. This is an essential biological process because it helps to avoid skin cancer and other associated conditions.
Pt 141 Features
The peptides activate the melanocortin receptors. This in turn has positive effects on libido, appetite and lipid metabolism. According to pt 141 research, the peptide is important in the tanning process and does not require any kind of exposure to harmful UV light. On the other hand, the peptide is important in inducing lordosis and is showing potential in becoming a remedy for sexual dysfunctions in men and women. The mechanism of action is through the stimulation of melanocortin receptors in the central nervous system and these receptors are essential in limiting and modulating the possibilities of developing ischemia. Further studies are being conducted on the possibility of using the pt 141 peptide as a smoothing agent. In this context, the peptide can be applied on the vaginal walls which will in turn alleviate arousal problems. Pt 141 allows researchers to conduct all the research required before it is allowed for use in any other purposes. The research is mainly focused on libido and sexually-related functions of the peptide.
It is observed that the administration of the pt 141 peptide acts on the central nervous system and induces tingling sensation, excitement and throbbing, among other sexual related characteristics. As per pt 141 reviews, it is supplied in 10 mg vials and 2 mg is often used in research. As indicated earlier, storing the peptide in a freezer when not in use is an important process in keeping its integrity intact. You can use 0.25 to 0.5 milligrams of the peptide on test mice or guinea pig subjects in the first attempt. You can increase the dosage until the desired effect is achieved. After 4 hours of administration, the peptide will peak in its activity and will bring about the desired effect and alleviate the problem. The peptide is available in numerous forms such as nasal sprays, pre-mixed versions and pills, among others.
Effects of Pt 141 on Sexual Dysfunctions
Penile erection is one of the most complex physiological processes. Understanding it will help in understanding how the pt 141 peptide works. Activation of the receptors in the central nervous system causes blood to rush to the gland. This in turn causes an erection. According to pt 141 reviews, the peptide has shown the ability to initiate spontaneous erections. While the central nervous system may act on MC3R and MC4R, there are numerous postulates which differ on the receptor being responsible for causing an erection. This inconclusive result is mainly because the activity of MC3R is not well-elucidated. New research showed that the pt 141 peptide causes antagonism of MC3R on the brain. The peptide has positive feedback in causing the erection. It acts on the oxytocinergic pathways in the brain stem, spinal and hypothalamic levels. The manipulation of melanocortin receptors is the new method of dealing with erectile dysfunction and this will provide a new approach for dealing with sexual dysfunction problems.
The melanocortin cholinergic system is essential in the mediation of various complexes and a wide variety of physiological effects. These may include salt regulation, skin pigmentation, penile erection, food intake regulation and sexual behavior. There are numerous effects which occur through the selective activation of 5-receptor subtypes. These are unique for the post-translational modification of the postprandial proopiomelanocortin gene. There is a high chance that the peptides will be beneficial in the understanding of various sub-types and how they will be used in modern drug research and drug design. The sub-types include beta MSH, ACTH, gamma MSH and alpha MSH. In the novel testing for a synthetic agent for tanning, the peptide resulted in an 8-hour long erection in the mice under study. It is believed that the activation of the melanocortin receptor by the peptide induced the erection.
Pt -141 reviews indicated that normal erection occurs when the peptide is administered. However, the longevity of the erection may differ depending on the type of receptor activated. The supraspinal regions are activated which in turn activates the parasympathetic and the sympathetic centers resulting in sexual behaviors. The neurotransmitter modulating the erection via the nitric oxide release the non-cholinergic and nonadrenergic nerves which activate the cavernosal smooth muscle cells to guanylyl cyclase. The enhanced production of cyclic nucleotide guanosine monophosphate and this results in cellular relaxation via calcium regulating channels which activates ejaculation. All the peptides supplied are for research purposes only and human consumption is prohibited.
PT-141 and Hemorrhagic Shock
One of the focuses of the scientific study on animal test subjects is to determine the link between pt-141 Bremelanotide and hemorrhagic shock. Essentially, the condition itself is marked by lower tissue perfusion which over time turns into an inadequate delivery of oxygen and nutrients vital for cellular function. The condition is split into four classes: neurogenic, cardiogenic, hypovolemic and vasogenic which is better known as septic. Overall, it is a very tricky ailment to deal with when it’s observed on a cellular level. That’s because no two cells will express the exact presentation of shock identically.
Scientific study based on animal test subjects has shown that pt-141 Bremelanotide design is to stimulate the neural reflects as a method to regulate blood flow through organs that would otherwise slow down or even shut down as a result of hemorrhagic shock. This particular manner of stimulation can manifest in several ways:
- A boosted heart rate
- A redistribution of blood flow away from organs that an animal test subject would deem to be unnecessary for ultimate survival, such as the skin or the kidneys
PT-141 Bremelanotide and Reperfusion Injury
Another main area of scientific study that was based on animal test subjects is to determine a link between pt-141 Bremelanotide and its conceived ability to lessen the effects of reperfusion injury. In essence, a reperfusion injury refers to the type of tissue damage that could be caused in the wake of an ischemic episode such as a stroke or angina pectoris. When this condition happens, a process that is normally considered important – the circulation of blood flow through an organ – actually results in oxidative damage and inflammation via the condition of oxidative stress.
It has been determined via a scientific study on animal test subjects that pt-141 Bremelanotide can work on a neurological level to lower the inhibitions that would otherwise be linked to the restriction of blood flow to tissues as a result of the ischemic cascade. The ultimate result of this process would translate to a lowering or even a blockage of resultant damage that may otherwise happen from blood flow limitation to potentially affected areas.
Other Focuses of Study
While studies of pt-141 Bremelanotide and its respective links to hemorrhagic shock and reperfusion injury are the most prominent fields of study regarding the peptide, it should be noted that some studies are focused on discovering a link between it and sexual dysfunction in both male and female animal test subjects. The pt 141 peptide is effective in accentuating the release of alpha melanocyte stimulating hormone. It is essential in the release of new cells in the nuclei and this is essential especially for reperfusion injuries as indicated earlier. Studies have shown that the peptide is under investigation for its potency and efficacy in releasing the melanocyte hormone that is essential for the growth of new cell lines. Cell lines promote growth and development in cells and tissues.